Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis

Abstract The success of implant performance and arthroplasty is based on several factors, including oxidative stress-induced osteolysis. Oxidative stress a key factor the inflammatory response. Implant biomaterials can release wear particles which may elicit adverse reactions in patients, such as local response leading to tissue damage, eventually results loosening implant. Wear debris undergo phagocytosis by macrophages, inducing low-grade chronic inflammation reactive oxygen species (ROS) production. In addition, ROS also be directly produced prosthetic biomaterial oxidation. Overall, amplify stimulate both RANKL-induced osteoclastogenesis osteoblast apoptosis, resulting bone resorption, periprosthetic Therefore, growing understanding mechanism osteolysis anti-oxidant strategies design well addition agents will help improve implants’ performances therapeutic approaches.